Publications utilizing NanoSomiX propriety technology (by disease state)
Acute Brain Injury:
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Mathew A. Edwardson, Masato Mitsuhashi, and Dennis Van Epps. Elevation of
astrocyte-derived extracellular vesicles over the first month post-stroke in humans.
Scientific Reports, nature portfolio (2024) 14:5272.
https://doi.org/10.1038/s41598-024-55983-w
- Hotta N, Tadokoro T, Henry J, et al. Monitoring of Post-Brain Injuries By Measuring Plasma
Levels of Neuron-Derived Extracellular Vesicles. Biomarker Insights. 2022;17.
https://doi.org/10.1177/11772719221128145
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Kawata, K., Mitsuhashi, M., Aldret, R. A preliminary report on
brain-derived extracellular vesicle as novel blood biomarkers for
sport-related concussions, Front. Neurol., 12 April 2018.
https://doi.org/10.3389/fneur.2018.00239
Alzheimer’s disease (AD):
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Kapogiannis D, Mustapic M, Shardell MD, et al. Association of
Extracellular Vesicle Biomarkers with Alzheimer Disease in the
Baltimore Longitudinal Study of Aging. JAMA Neurol.
2019 Jul 15. DOI:
10.1001/jamaneurol.2019.2462
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Hamlett, E., Goetzl, E. et.al. Neuronal exosomes reveal Alzheimer’s
disease biomarkers in Down syndrome, Alzheimer’s & Dementia,
10/17/2016
http://dx.doi.org/10.1016/j.jalz.2016.08.012
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Goetzl EJ, Kapogiannis D, Schwartz JB, et al. Decreased synaptic
proteins in neuronal exosomes of frontotemporal dementia and
Alzheimer’s disease. The FASEB Journal, Dec. 2016
, doi: 10.1096/fj.201600816R
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Abner EL, Jicha GA, et al. Plasma neuronal exosomal levels of
Alzheimer’s disease biomarkers in normal aging. Annals of Clinical and
Translational Neurology, 2016,
https://doi.org/10.1002/acn3.309
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Winston CN, Goetzl, EJ, et al. Prediction of conversion from mild
cognitive impairment to dementia with neuronally derived blood exosome
protein profile. Alzheimer’s & Dementia (Diagnosis, Assessment
& Disease Monitoring) 2016
http://dx.doi.org/10.1016/j.dadm.2016.04.001
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Goetzl EJ, Boxer a, Schwartz JB, et al. Altered lysosomal proteins in
neural derived plasma exosomes in preclinical Alzheimer disease.
Neurology 2015;
doi:10.1212/WNL.0000000000001702
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Goetzl EJ, Boxer A, Schwartz JB, et al. Low neural exosome levels of
cellular survival factors in Alzheimer’s disease. Annals of Clinical
and Translational Neurology, 2015,
doi: 10.1002/acn3.211
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Kapogiannis, et. al. The FASEB Journal, 2014: Dysfunctionally
phosphorylated type 1 insulin receptor substrate in neural-derived
blood exosomes of preclinical Alzheimer’s disease,
https://doi.org/10.1096/fj.14-262048
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Fiandaca, et.al. Alzheimer’s & Dementia, 2014:
Identification of preclinical Alzheimer’s disease by a profile of
pathogenic proteins in neurally derived blood exosomes: A case-control
study, DOI:
https://doi.org/10.1016/j.jalz.2014.06.008
Amyotrophic Lateral Sclerosis (ALS):
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Katsu M, Hama Y, Utsumi J et al. MicroRNA expression profiles of
neuron-derived extracellular vesicles in plasma from patients with
amyotrophic lateral sclerosis. Neuroscience Letters, August 2019, vol
708
https://doi.org/10.1016/j.neulet.2019.03.048
Major Depressive Disorder (MDD):
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Kuwano N, Kato TA, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K,
Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S. Neuron-related blood
inflammatory markers as an objective evaluation tool for major
depressive disorder: An exploratory pilot case-control study. J Affect
Disord. 2018 Jul 17;240:88-98.
https://doi.org/10.1016/j.jad.2018.07.040
Parkinson’s disease and Related Disorders:
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Ohmichi, T., Mitsuhashi, M. et al., Quantification of brain-derived
extracellular vesicles in plasma as a biomarker to diagnose Parkinson's
and related diseases, Parkinsonism & Related Disorders, April 2019;
61: 82-87
https://doi.org/10.1016/j.parkreldis.2018.11.021